January 5, 1986

Brian M. Susskind

Assistant Professor, Surgery

and Microbiology and Immunology Medical College

of Virginia

Box 629, MCV Station

Richmond, VA 23298

Dear Brian:

Enclosed please find January’s check for our contracted research.

Fortunately, we now have all other research grants paid off, including

Bowman Gray School of Medicine, yours remaining.

Hopefully I’ll be able to continue paying you — but please keep in mind that we

are in continuous court battle with [deleted] , and the problems do not seem to go

away.

Reference your letter of 12/29/86 to Paul

Pybus: Your comments via effects on macrophages are certainly appropo. As I

recall, Roger Wyburn-Mason inserted metronidasole in one knee but not the

other, and the inflammation

was quenched (but it might have been clotrimasole) Whether one or the other, the

main findings with Pybus/Davis and Kwang Jeon is that

knee effusions containing metronidasole (systemically) had no living macrophages

and no growth in the laboratory, whereas those without

treatment by metronidasole had living macrophages and they grew (or similar organisms) grew

in the laboratory.

According to Pybus’ report when speaking to Smith of Bowman Gray, Clotrimasole did not

have the same effects.

So I was a little bewildered why the reference to Clotrimasole with respect to the “killing of macroph-

ages.”

Cordially,

Perry A. Chapdelaine, Sr.